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Lagos is about 2 hour and 40 minutes drive from the Lisbon airport. There are a number of option to reach Lagos. These include a domestic flight to Faro airport, Hire Car, Train or Bus.
There are many car hire companies that can be used to pick up a hire car and then drive to Lagos.
The fastest route from Lisbon to Lagos is via the A2 toll expressway, which passes through the interior of southern Portugal.
The journey takes approximately two and half hours and is a smooth run. There are a number of toll points during the trip and having a transponder that automatically pays the tolls is by far the easier way to travel as many toll points do not have manned or coin-operated toll gates. Most hire cars will include a transponder. Be sure to enquire about this is advance and understand how it works.